Thursday, June 6

13:00 – 17:00   YIN (Young investigators network)

Chairs: Denis Malaise and Natasha van Poppelen

13.00-13.05     Welcome from the organizing committee

13.05-13.15     Welcome from the YIN


13.15-14.00     Keynote lecture: Thierry van den Bosch

                           Eyes on the Map: Exploring Spatial Transcriptomics

14.00-14.30     YIN business


14.30-15.10       Coffee


15.00-17.00     Basic research presentations

Chairs: Ulrich Pfeffer and Denis Malaise

15.10                 Laura Hoffmann

                           Experiences with an artificial intelligence-based assistant to distinguish choroidal nevi from uveal melanoma

15.20                 Erwin Brosens

                           Uveal Melanoma zebrafish xenograft models illustrate mutation status dependent effects of compound synergism or – antagonism

15.30                 Adriana Amaro

                           Molecular evidence for blue light as an etiological factor for uveal melanoma

15.40                 Quincy van den Bosch

                           Transcription regulators FOXD1 and RBFOX2 contribute to metastatic capacity in high-risk Uveal Melanoma

15.50                 Rui Wang

                           MiR-181a-driven downregulation of cholesterol biosynthesis through the inhibition of SREBP2 suppresses UM metastasis

16.00                 Mike Wu

                           Clinical applicability of methylated cell-free DNA (cfDNA) in uveal melanoma (UM) using methylated DNA sequencing (MeD-seq)

16.10                 Monica Maria Pagliara

                           Impact on metastatic risk of tumor microenvironment biomarkers and chromosomal aberrations in uveal melanoma

16.20                 Emine Kilic

                           Dosimetric patterns for Toxicity-specific Profiles in Uveal Melanoma following Stereotactic Radiotherapy

16.30                 Anna Hagström

                           Melatonin receptor expression in primary uveal melanoma

16.40                 Natasha van Poppelen

                           The effect of proton beam therapy on cell metabolism of Müller cells and organoids derived from uveal melanoma cells

16.50                 Stine Dahl Vest

                           The genetic profile of large B-cell lymphomas presenting in the ocular adnexa


17.30-20.00    Welcome reception at Haga Bottega.



Friday, June 7

Chairs: Bertil Damato and Gustav Stålhammar

09:00 – 09:30   New approaches for proton beam therapy planning

                           Jan-Willem Beenakker & Martin Janson

09:30 – 10:30   Uveal melanoma presentations

09.30                 Bertil Damato

                           Risk of metastatic death from small choroidal melanomas if treatment is deferred until tumor growth is detected: a study using LUMPO

09.40                 Gustav Stålhammar

                           Choroidal Nevi and Melanoma Doubling Times and Implications for Delays in Treatment: A Systematic Review and Meta-analysis

09.50                 Suzanne Phillips

                           A phase Ib study of endogenous T cell therapy using SLC45A2-specific CD8 memory T cells for patients with metastatic uveal melanoma

10.00                 Paweł Rogala

                           Retrospective Analysis of Tebentafusp Treatment in Metastatic Uveal Melanoma: One Center Study

10.10                 Roderick O’Day

                           Darovasertib for localized Ocular Melanoma

10.20                Giulia Midena

                          Aqueous humor proteomic findings at diagnosis correlate with subsequent metastases of uveal melanoma


10.30-11.00     Coffee


Chair: Alexandre Moulin

11:00 – 11:30   Keynote lecture: Bita Esmaeli

                           Immunotherapy and targeted therapy for locally advanced or metastatic ocular adnexal cancers

11.30-12.00     OOG Poll session


12:00 – 13:00 Lunch

Chairs: Alexandre Moulin and Rob Verdijk

13:00 – 13:30   OOG Collaborative Initiatives, discussions about (future) joint projects

13:30-14:00     Keynote lecture: Bertil Damato

                           My forty years in ocular oncology – a case report

14:00 – 15:00   Uveal melanoma presentations continued

Chairs: Tero Kivela and Iwona Rospond-Kubiak

14.00                 Joni Turunen

                           Genetic predisposition to uveal melanoma in Finland

14.10                 Alexandre Matet

                           Identification of the monoallelic MBD4-associated neoplasia syndrome in uveal melanoma: from exceptional responders to familial predisposition

14.20                 Mari Mansikkamäki

                           Brachytherapy for juxtapapillary choroidal melanoma: comparison of slotted iodine and slotted ruthenium plaque radiotherapy

14.30                 Vincenzina Mazzeo

                           Multiple tumors in uveal melanoma patients.

14.40                 Paul Foerster

                           First experience with self-shielding gyroscopic radiosurgery for uveal melanoma

14.50                 Jens Heufelder

                           Milestones and patient statistics of 25 years ocular proton therapy in Berlin


15.00-15.30     Coffee


15:30 – 17:00   Uveal melanoma presentations continued

Chairs: Heinrich Heimann and Ann Schalenbourg

15.30                 Firas Kreidieh

                           Tumor infiltrating lymphocyte harvest and ex vivo expansion from primary and metastatic uveal melanoma tumors

15.40                 Ekaterina Sokolenko

                           Radiation Shielding for Ocular Brachytherapy

15.50                 Min Kim

                           The Spectrum of Vitreoretinal Diseases and Benign intraocular Tumors often misdiagnosed as intraocular malignancies

16.00                 Corné Haasjes

                           Optical aberration correction in fundus photographs for ocular proton therapy planning

16.10                 Tero Kivelä

                           Presumed incipient choroidal melanomas: an update

16.20                 Guy Missotten

                           Growing juxtapapillary tumors: melanocytoma or melanoma

16.30                 Emilia Zwolinska

                           Malignant transformation of low-risk choroidal nevi – a case series

16.40                 Michał Dopierała

                           Diagnostic Biopsy for Indeterminate Choroidal Melanocytic Lesions: A Case Series

16.50                 Susan Kennedy

                           Clinico-Pathologic and Molecular Analysis of enucleated Small (T1) Uveal Melanomas

17.00                 Ann Schalenbourg

                           Clinical outcomes in AYAs (adolescent and young adults) treated with proton therapy for uveal melanoma: a comparative matching study with elder adults


19:00 – 23:00    Dinner at Vasa Museum



Saturday, June 8

Chair: OOG board

09:00 – 10:00   OOG business meeting

Chair: Vicktoria (Vicky) Vishnevskia-Dai

10:00 – 10:30   Keynote lecture, Doris Hadjistilianou

                           Cancer in Greek mythology: The retinoblastoma paradigm


10:30 – 11:00   Coffee


11.00-12.00     Retinoblastoma presentations

Chairs: Nathalie Cassoux and Alexandre Matet

11.00                 Nathalie Cassoux

                           Diffuse infiltrating retinoblastoma with anterior chamber involvement: conservative management and identification of RB1 alterations in aqueous humor

11.10                 Su-Chan Lee

                           BCOR loss promotes retinoblastoma growth by induction of IGF1 expression and activation of IGF1 receptor signaling

11.20                 Adeline Berger

                           Spatial transcriptomics in a poorly differentiated retinoblastoma with a retinocytoma area: a case study

11.30                 Paulina Bartoszek

                           Late intraocular recurrence of retinoblastoma in a teenager

11.40                 Vicktoria (Vicky) Vishnevskia-Dai

                           Orbital Development in Children with Retinoblastoma: An Imaging-Based Study

11.50                 Iwona Rospond-Kubiak

                           Orbital MRI vs ophthalmic ultrasound for the evaluation of intraocular tumors in eyes with opaque optic media

12.00-12.30     Delcath Symposium


12:30 – 13:30 Lunch


13:30 – 14:30   Rapid fire session (5+1 min. presentations)

Chairs: Steffen Heegaard and Rob Verdijk

13.30                 Gustavo Savino

                           Breast cancer orbital metastases: clinical, imaging and histopathological features in a retrospective case series

13.36                 Hilary Reeves

                           True frequency of HLA-A*02:01 expression in metastatic uveal melanoma patients

13.42                 Viktor Gill

                           Incidence, Risk Factors and Outcomes of Cataract Surgery after Plaque Brachytherapy for Posterior Uveal Melanoma

13.48                 Shiva Sabazade

                           Deep Learning for Distinguishing Small Choroidal Melanomas from Nevi in Fundus Photographs: Development and Validation of an Accurate Algorithm

13.54                 Rumana Hussain

                           The Ocular oncology biobank and the development of a trusted research environment

14.00                 Alexandra Steinemann

                           Presentation of three Patients with Finding of Undifferentiated Carcinoma

14.06                 Arnaud Martel

                           Post-radiation management of scleral necrosis with deep temporal aponeurosis and vascularized conjunctival flap

14.12                 Luise Grajewski

                           The Risk of Recurrence of Conjunctival Melanoma after Excision and Adjuvant Brachytherapy with Ruthenium-106

14.18                 Gustav Stålhammar

                           Tailoring Metastatic Surveillance in Uveal Melanoma Based on Individual Metastatic Risk

14.24                 Coen Rasch

                           Two years of proton therapy in The Netherlands, clinical results


14.30-15.00     Coffee


15:00 – 17:00   Periocular and orbital tumors presentations

Chairs: Hayyam Kiratli and Edoardo Midena

15.00                 Heinrich Heimann

                           Proton beam radiotherapy for advanced ocular surface malignancies

15.10                 Raffaele Parrozzani

                           Subthreshold Micropulse Laser as a Novel Treatment of Radiation Macular Edema                                         
                           Radiation Shielding for Ocular Brachytherapy

15.20                 Edoardo Midena

                           Adjuvant Iodine-125 Brachytherapy in Conjunctival Melanoma

15.30                Jan-Willem Beenakker

                           MR-Imaging characteristics of intra-ocular tumours

15.40                 Guy Negretti

                           Intravitreal Bevacizumab for The Treatment of Choroidal Haemangiomas

15.50                Antonia M. Joussen
                          How to maintain function in eyes after irradiation for chroidal melanoma

16.00                 Hayyam Kiratli

                           Yolk Sac Tumor of the Eye and Orbit: Diagnosis and management of Four Patients

16.10                 Li Teng Kok

                           Eyelid merkel cell carcinoma: Management and outcomes in a tertiary eye centre

16.20                 Denis Malaise

                           Choroidal MALT lymphoma: various clinical presentations of a rare disease

16.30                 Steffen Heegaard

                           Ocular adnexal T-cell lymphomas

16.40                 Maya Eiger-Moscovich

                           Seasonal variation in vitreoretinal lymphoma diagnosis

16.50                 Robert Verdijk

                           Evidence of MAPK pathway activation across subtypes of adult orbital xanthogranulomas irrespective of the presence of oncogenic mutations


19:30 – 23:00   Dinner at Nobel Price Museum


Sunday, June 9

10:00 – 12:00 Guided tour, St. Erik Eye Hospital






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